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Treating biofilms is one of the significant challenges facing modern medicine, as they are often resistant to antibiotics. Their extracellular matrix protects them from the immune system as well as from various treatments, and they contribute greatly to chronic infections in various organs: from urinary tract, CF patients, joint infections, bone infections and a variety of implant infections.
The clinical treatment of phages today includes the personal matching of phages for the target bacterium, so that treatment is most suitable for the patient. In biofilm treatment this is a significant challenge due to long growth times, long treatment times, lack of high resolution tools that estimate biofilm degradation to accurately differentiate between different phages or combinations of phages and antibiotics.
Also, some bias is present in phage isolation process, as they are isolated against bacteria in a mainly planktonic growth state.
We will try to find and invent tools to deal with the challenges described above.
