Antibiotic resistance is currently one of the greatest threats to global health. It prolongs hospital stays, complicates patient treatment, and leads to the deaths of hundreds of thousands of people each year. Given the severity of this problem, there is an urgent need to find new and effective solutions for treatment.
One of the promising solutions to this crisis today is phage therapy, the use of bacterial viruses (phages) as antimicrobial agents. Phage therapy has a number of advantages: 1. phages are reproducing elements that are relatively easy to isolate and can be genetically improved through molecular engineering. 2. effective decomposition of biofilm, and 3. high specificity, ensuring minimal impact on the microbiome. These advantages enable and dictate a dynamic and personalized treatment regimen and allow us to combat emerging resistance.
At the Phage Therapy Laboratory, we are working to promote phage therapy in Israel and worldwide. We work with a variety of pathogenic and environmental bacteria and study their interactions with phage. As part of our laboratory research, we isolate new phages from nature and characterize them using molecular, microbiological, virological, and microscopic methods. We study a variety of delivery routes, phage stability, and their efficacy against a wide range of pathogens in vitro and in vivo experiments.
Due to the high specificity of phages and to achieve optimal results, we adopted a personalized treatment approach. A key element of this approach is the development of a large phage bank.
Therefore, we established the Israeli Phage Bank (IPB), which is one of the largest in the world and contains over 500 phages against a broad spectrum of bacteria. The phages were collected using traditional methods and new sophisticated screening methods that we developed specifically for this project.
With these phages, we have so far treated 13 patients in Israel and have been involved in the treatment of several patients around the world, including the United States, Australia and Germany. In addition, the phages from the bank are currently being used for various studies and veterinary applications.
In addition to the use of phages in human medicine, we are also investigating other applications in areas such as agriculture, veterinary medicine and more.
Although we are mainly concerned with phages in the laboratory, there are other areas of interest. One important and exciting area is bioarchaeology.
Lab manager
Lab manager
Ph.D student, MBA.
Ph.D student and manager of the Israeli Phage Bank.
MD-Ph.D student
Masters student
Ph.D student
Masters student
PhD, PhD, LLM, LLB
MD
Mohanad Abd AL Rahman 2019 – 2022
Leron Khalifa PhD student 2014 – 2021
Mor Shlezinger (DMD) PhD student 2016 – 2021
Niv Gronovich (Alpha program) 2016 – 2020
Shira Ben Porat (Tzameret, MD) 2016 – 2020
Reut Kraitman (DMD) 2017 – 2020
Naama Gold 2017 – 2019
Hadar Iram 2017 – 2020
Chaya Schoemann Taub 2014 – 2020
Vanda Lerer 2017 – 2019
Alexia Azulai (MA) 2016 – 2018
Elisheva Dorfman (MA) 2016 – 2018
Fatima abu khdeir (MA) 2015 – 2017
Noa Amira and Michal Shneor (Hadassah College) 2015 – 2016
Axel Dassel (Post Doc) 2015 – 2016
Omri Adini (Pre student) 2015 – 2016
Karine Rodney (DMD) 2015 -2016
Yair Brosh (DMD project) 2014
Chaya & Menuha (Hadassah college, Haradic wing) 2015 – 2016
Sharon Kahan (Pre-student) 2015 – 2016
Sahar Magen (Hadassah Academic College) 2016 – 2017
Zipora Ablek (Hadassa Colleage) 2016 – 2017
David Domb (Pre-clinical student of dentisry) 2015 – 2016