404 Lab site

About 404 lab
the Phage therapy lab

Antibiotic resistance is currently one of the greatest threats to global health. It prolongs hospital stays, complicates patient treatment, and leads to the deaths of hundreds of thousands of people each year. Given the severity of this problem, there is an urgent need to find new and effective solutions for treatment.

One of the promising solutions to this crisis today is phage therapy, the use of bacterial viruses (phages) as antimicrobial agents. Phage therapy has a number of advantages: 1. phages are reproducing elements that are relatively easy to isolate and can be genetically improved through molecular engineering. 2. effective decomposition of biofilm, and 3. high specificity, ensuring minimal impact on the microbiome. These advantages enable and dictate a dynamic and personalized treatment regimen and allow us to combat emerging resistance.

At the Phage Therapy Laboratory, we are working to promote phage therapy in Israel and worldwide. We work with a variety of pathogenic and environmental bacteria and study their interactions with phage. As part of our laboratory research, we isolate new phages from nature and characterize them using molecular, microbiological, virological, and microscopic methods. We study a variety of delivery routes, phage stability, and their efficacy against a wide range of pathogens in vitro and in vivo experiments.

Due to the high specificity of phages and to achieve optimal results, we adopted a personalized treatment approach. A key element of this approach is the development of a large phage bank.

Therefore, we established the Israeli Phage Bank (IPB), which is one of the largest in the world and contains over 500 phages against a broad spectrum of bacteria. The phages were collected using traditional methods and new sophisticated screening methods that we developed specifically for this project.

With these phages, we have so far treated 13 patients in Israel and have been involved in the treatment of several patients around the world, including the United States, Australia and Germany. In addition, the phages from the bank are currently being used for various studies and veterinary applications.

In addition to the use of phages in human medicine, we are also investigating other applications in areas such as agriculture, veterinary medicine and more.

Although we are mainly concerned with phages in the laboratory, there are other areas of interest. One important and exciting area is bioarchaeology.

Our team

ronen chazan

Prof. Ronen Hazan

Shunit Coppenhagen-Glazer, Lab manager

Dr. Shunit Coppenhagen-Glazer

Lab manager


Shunit Coppenhagen-Glazer

Lab manager

Sivan Alkaly – Oren. Ph.D student, MBA

Sivan Alkaly – Oren

Ph.D student, MBA.

Ortal Yerushalmy. Ph.D student and manager of the Israeli Phage Bank

Ortal Yerushalmy

Ph.D student and manager of the Israeli Phage Bank.

Amit Rimon. MD-Ph.D student

Amit Rimon

MD-Ph.D student

Eden Rosenberg. Masters student

Eden Rosenberg

Masters student

Tzemach Aouizerat, Ph.D student

Tzemach Aouizerat

Ph.D student


Ron Braunstein

Masters student

Dr. Eyal Katvan, (PhD, PhD, LLM, LLB)

Dr. Eyal Katvan



Chani Rakov

Daniel Gelman MD

Daniel Gelman


Mohanad Abd AL Rahman   2019 – 2022

Leron Khalifa PhD student   2014 – 2021

Mor Shlezinger (DMD) PhD student   2016 – 2021

Niv Gronovich (Alpha program)  2016 – 2020

Shira Ben Porat (Tzameret, MD)  2016 – 2020

Reut Kraitman (DMD)  2017 – 2020

Naama Gold  2017 – 2019

Hadar Iram  2017 – 2020

Chaya Schoemann Taub  2014 – 2020

Vanda Lerer  2017 – 2019

Alexia Azulai (MA)  2016 – 2018

Elisheva Dorfman (MA)  2016 – 2018

Fatima abu khdeir (MA)  2015 – 2017

Noa Amira and Michal Shneor (Hadassah College)  2015 – 2016

Axel Dassel (Post Doc)  2015 – 2016

Omri Adini (Pre student)  2015 – 2016

Karine Rodney (DMD)  2015 -2016

Yair Brosh (DMD project)  2014

Chaya & Menuha (Hadassah college, Haradic wing)  2015 – 2016

Sharon Kahan (Pre-student)  2015 – 2016

Sahar Magen (Hadassah Academic College)  2016 – 2017

Zipora Ablek (Hadassa Colleage)  2016 – 2017

David Domb (Pre-clinical student of dentisry)  2015 – 2016

Funders and Collaboration